NSIDRC Journal Article Alert — October 26, 2007

Past issues of NSIDRC journal alerts are available at: http://www.sidscenter.org/

O'leary CM, Bower C, Knuiman M, Stanley FJ.
*Changing risks of stillbirth and neonatal mortality associated with maternal age in Western Australia 1984-2003.
*Paediatr Perinat Epidemiol. 2007 Nov;21(6):541-9.

There has been a trend over the past two decades in some Western countries for women to delay childbearing, a factor associated with an increased risk of perinatal mortality (stillbirth and neonatal death). While the rates of stillbirth and neonatal mortality have improved in some countries, it has not been established whether maternal age remains a risk factor for perinatal mortality in Australia. The Western Australian Maternal and Child Health Research Database (MCHRDB) was used to examine the effect of maternal age on perinatal death in the periods 1984-93 and 1994-2003 after adjustment for parity and sociodemographic factors. Stillbirths and neonatal deaths were analysed separately. The crude rate of stillbirth has shown little change over the 20 years examined remaining at around 7.5 per 1000 total births, while the rate of neonatal death has decreased steadily from 5.4 per 1000 livebirths in 1984 to 2.0 in 2003. Older maternal age remains a risk factor for stillbirth but the relative risk has declined. After adjustment for parity and sociodemographic factors the relative risk of stillbirth for a woman aged over 40 years (compared with a woman aged 25-29 years) decreased from 2.6 in the period 1984-93, to 1.9 in the period 1994-2003. The increased risk of stillbirth associated with teenage mothers was fully explained by sociodemographic factors in both time periods. No increased risk of neonatal death was evident in the recent period 1994-2003 for teenage or older mothers after adjustment for parity and sociodemographic factors. In spite of some improvements over the past 20 years, women 30 years of age and older continue to be at increased risk of stillbirth. The risk of neonatal death is no longer associated with increased maternal age; however, the small number of cases in the older maternal age groups may be a result of the increased prevalence of antenatal screening and terminations for birth defects.

Full-text available at: http://www.blackwell-synergy.com/

Hilliard N, Jenkins R, Pashayan N, Powles.
*Informal knowledge transfer in the period before formal health education programmes: case studies of mass media coverage of HIV and SIDs in England and Wales.*
BMC Public Health. 2007 Oct 17;7(1):293 [Epub ahead of print] .

ABSTRACT: BACKGROUND: How advances in knowledge lead via behaviour change to better health is not well understood. Here we report two case studies: a rapid reduction in HIV transmission in homosexual men and a decline in Sudden Infant Death Syndrome (SIDS) that took place in the period before the relevant national education programmes commenced, respectively, in 1986 and 1991. The role of newspapers in transferring knowledge relevant to reducing the risk of AIDS and SIDS is assessed. METHODS: HIV Searches were made of The Times (1981-1985), Gay News (1981-1984) and, for the key period of April to June 1983, of eight newspapers with the highest readership. Information on transmission route and educational messages were abstracted and analysed. SIDS Searches were made of The Times and the Guardian (1985-1991), The Sun (selected periods only, 1988-1991) and selected nursing journals published in England and Wales. Information on sleeping position and educational messages were abstracted and analysed. RESULTS: HIV Forty-five out of 50 articles identified in newspapers described homosexuals as an at risk group. Sexual transmission of AIDS was, however, covered poorly, with only 7 (14%) articles referring explicitly to sexual transmission. Only seven articles (14%) associated risk with promiscuity. None of the articles were specific about changes in behaviour that could be expected to reduce risk. Gay periodicals did not include specific advice on reducing the number of partners until early 1984. SIDS Out of 165 relevant articles in The Times and 84 in the Guardian, 7 were published before 1991 and associated risk with sleeping position. The reviewed nursing journals reflected a pervasive sense of uncertainty about the link between SIDS and sleeping position. CONCLUSIONS: Presumptively receptive audiences responded rapidly to new knowledge on how changes in personal behaviour might reduce risk, even though the 'signals' were not strong and were transmitted, at least partly, through informal and 'horizontal' channels. Advances in knowledge with the potential to prevent disease by behaviour change may thus yield substantial health benefits even without the mediation of formal education campaigns ('interventions'). Formal campaigns, when they came, did make important additional contributions, especially in the case of SIDS.

Full-text available at: http://www.biomedcentral.com/

Altomare I, Adler A, Aledort LM.
*5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature.
*Thromb J. 2007 Oct 17;5(1):17 [Epub ahead of print] .

ABSTRACT: BACKGROUND: The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagulated during pregnancy. Objectives: We report a series of 8 patients with this issue and review the current literature. Methods: 8 patients (3 of whom were actively pregnant) were referred with histories of spontaneous fetal loss; hypercoaguability work-ups revealed each were homozygous for the MTHFR C677T mutation without other thrombophilias. Results: In the 3 women who have conceived, treatment with LMW heparin during pregnancy led to two full-term births and one additional pregnancy without complication. For the 5 who have not, we recommended treatment with LMW heparin upon conception. Conclusions: We provide evidence to support the relationship between MTHFR C677T mutations and recurrent fetal loss, and to suggest that anticoagulation of these patients during pregnancy can lead to a successful pregnancy outcome.

Full-text available at: http://www.thrombosisjournal.com/

Bergner A, Beyer R, Klapp BF, Rauchfuss M.
*Pregnancy after early pregnancy loss: A prospective study of anxiety, depressive symptomatology and coping.
*J Psychosom Obstet Gynaecol. 2007 Oct 16;:1-9 [Epub ahead of print].

Miscarriages can have lasting psychological effects on those concerned. In a prospective longitudinal study, 342 women were questioned about the way in which they coped after an early miscarriage (up to the 16th week of gestation), a few weeks after the pregnancy loss. There are data available from the first trimester of a subsequent pregnancy for 108 of these women. Standardized symptom scales were used to explore the pregnancy-specific anxiety, state and trait anxiety (STAI) and depressive symptoms in pregnant women and these were compared with the symptoms of 69 pregnant women with no history of miscarriages. Women with a history of miscarriages suffer more from pregnancy-specific anxieties in the first trimester of a new pregnancy than pregnant women with no history of miscarriages. Patterns of "depressive coping" and "anxious grieving" after the losses are predictive of more marked anxiety and depression symptoms in the first trimester of a subsequent pregnancy. These results suggest that women who have had an early miscarriage are particularly at risk of disturbances in their psychological adaptation in a new pregnancy. It is possible to determine risk factors which can be used to recognize those women who are particularly at risk directly after the miscarriage.

Full-text available at: http://www.informaworld.com/

Nayama M, Tamakloé-Azamesu D, Garba M, Idi N, Djibril B, Kamayé M, Marafa A, Touré A, Diallo FZ, Houfflin-Debarge V.
*Abruptio placentae. Management in a reference Nigerien maternity. Prospective study about 118 cases during one year.
*Gynecol Obstet Fertil. 2007 Oct 2; [Epub ahead of print].

OBJECTIVE: Placental abruption is a syndrome, which occurs in the third trimester of the pregnancy or during labour. It is the main cause of pregnancy last term bleeding and is also responsible for a high stillbirth rate. The objective is to describe the epidemiological, clinical, paraclinical and therapeutic characteristics in order to decrease the fetal and maternal mortality and morbidity. PATIENTS AND METHODS: It is a prospective and descriptive study in continuous series, over a twelve-month period, from 1st January 2003 to 31st December 2003, at Issaka Gazobi maternity of Niamey, Niger. RESULTS: During the study period, 3255 deliveries have been done. One hundred and eighteen placental abruptions have been observed, which corresponds to a frequency of 3.6% with the highest rate during raining season. The average age and parity were: 31 years and 5th with a predominance of grand multiparous (38.2%). The majority of the patients were in-utero transfers (83,1%) and had done at least 10 km before arriving. One hundred and eleven patients had a caesarean section (94,1%) and 7 delivered through the vaginal route (5.9%). The fetal prognosis was characterized by a high stillbirth rate of 71.3% (87/122), fetal hypotrophy (64.8%) and prematurity (23.8%). The main cause of maternal morbidity was anaemia (76.3%) and Disseminated Intravascular Coagulation (5.9%). Further, 81 patients have been transfused (68.7%). The maternal mortality was 5.1% (6/118). DISCUSSION AND CONCLUSION: Placental abruption, a medical and obstetrical emergency, is a serious obstetric condition, especially in our country. Physicians must be aware that patients with high blood pressure, preeclampsia, eclampsia, particularly in case of multiparity are at increased risk of placental abruption. Early diagnosis, prenatal follow-up and caesarean section improve the maternal and fetal prognosis.

Full-text available at: www.sciencedirect.com/ <http://www.sciencedirect.com/>

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