NSIDRC Journal Article Alert — January 23, 2009
Prepared by the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University.
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Sudden Infant Death
1. Edwards S, McCreanor T, Ormsby M, Tuwhangai N, Tipene-Leach D
Maori men and the grief of SIDS
Death Stud. 2009 Feb;33(2):130-52
Whariki Research Group, Massey University, Auckland, New Zealand. kawhiamonan@yahoo.com.au
The loss of a baby is always hard to cope with and the grieving process is likely to be difficult. Interventions to work with Sudden Infant Death Syndrome (SIDS) families have improved grieving outcomes for many but the needs of Maori fathers are not well understood or catered to by existing services. This article presents narrative data from Maori fathers who have lost a baby to SIDS and analyzes these narratives in the context of the literature and of traditional Maori constructs about grief. The authors document a rarely discussed Maori concept, "the attainment of mauri tau," as the desired outcome of the grieving process; and begin a discussion around the changing face of the Maori grieving process and its implications for the grieving practices of Maori men.
Miscarriage/Stillbirth/Prenatal Issues
1. Cupisti S, Fasching PA, Ekici AB, Strissel PL, Loehberg CR, Strick R, Engel J, Dittrich R, Beckmann MW, Goecke TW
Polymorphisms in estrogen metabolism and estrogen pathway genes and the risk of miscarriage
Arch Gynecol Obstet. 2009 Jan 18. [Epub ahead of print]
Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21-23, 91054, Erlangen, Bavaria, Germany.
PURPOSE: This study investigated genetic variations in the estrogen pathway and their association with miscarriages. METHODS: A total of 483 patients were recruited from a comprehensive control group for case-control studies. Three variants of the CYP19A1 gene (rs10046, rs4646 and rs700519) and one variant each of the estrogen (ESR1) and progesterone (PGR) receptor genes (rs3020314 and rs1042838) were investigated using polymorphism genotyping. The chi-squared test and one-way analysis of variation (ANOVA) were used for statistical analysis. RESULTS: For rs10046 (CYP19A1), the C/C genotype was associated with a greater frequency of miscarriages (P = 0.017). The other genotypes were not found to be associated with recurrent miscarriage. CONCLUSIONS: This is the first study that has identified a single-nucleotide polymorphism in the aromatase gene that suggests a significant association between genotypes and miscarriage. As aromatase is an essential enzyme in the estrogen pathway, it may be speculated that variations in the aromatase gene in some way give rise to different conditions in the endocrine environment that can lead to impaired fertility.
2. Yadav S, Choudhary D, Narayan
KC, Mandal RK, Sharma A, Chauhan SS, Agrawal P
Adverse reproductive outcomes associated with teenage pregnancy
Mcgill J Med. 2008 Jul;11(2):141-4
INTRODUCTION: It is debated whether teenage pregnancy is associated with an adverse reproductive outcome. This study assessed the reproductive outcomes in teenage pregnancy in Nepal, a developing setting. METHODS: A hospital based retrospective cohort study of 4,101 deliveries to compare the outcomes between teenage and non-teenage pregnancies. RESULTS: Pregnancy in teenagers was associated with significantly increased risk (P<0.05) of delivery of very and moderately preterm births and Low Birth Weight babies. There was no significant difference in risk of having small for gestational age babies, low APGAR score at birth at 1 min and 5 min, stillbirth, neonatal death, and post partum hemorrhage. However, the risk of having delivery by episiotomy, vacuum or forceps and Caesarean section was significantly lower (P<0.05) among teenage mothers. CONCLUSION: Teenage women were more likely to have preterm births and low birth weight babies. However, they were less likely to have delivery by episiotomy, forceps or vacuum and Caesarean sections. In other respects, there were no significant differences between teenage and non-teenage mothers.
3. Martínez R, Bonilla-Henao
V, Ramos I, Sobrino F, Lucas M, Pintado E
May anomalous X chromosome methylation be responsible for the spontaneous abortion of a male foetus?
J Genet. 2008 Dec;87(3):261-4
Departamento de Bioquimica Médica y Biología
Molecular, Facultad de Medicina, Avda. Sanchez Pizjuán,
4 E-41009, Sevilla, Spain. elizabet@us.es.
4. Benkhalifa M, Demirol A, Ménézo Y, Balashova
E, Abduljalil AK, Abbas S, Giakoumakis I, Gurgan T
Natural cycle IVF and oocyte in-vitro maturation in polycystic ovary syndrome: a collaborative prospective study
Reprod Biomed Online. 2009 Jan;18(1):29-36
ATL R&D, Reproductive Biology and Genetics Laboratory, La Verriere, France.
In-vitro maturation (IVM) was performed in 350 cycles for 262 unstimulated patients diagnosed with polycystic ovary syndrome who were primed with human chorionic gonadotrophin (HCG) before oocyte retrieval. In order to improve nuclear and cytoplasmic maturation, growth hormone was added to the maturation medium. Oocytes were recovered in 94.8% of the cycles, with a mean number of nine cumulus-oocyte complexes retrieved. Within 28 h, 62% of the oocytes reached the metaphase II (MII) stage, and 17.6% were MII after a further 20 h in culture. An ongoing pregnancy rate of 15.2% was obtained, but with a high miscarriage rate, 28% of the total with a positive betaHCG test assessed after embryo transfer. Cytogenetic and DNA fragmentation analysis of the embryos was not fundamentally different from what is classically observed in routine IVF. This observation implies that the results are not necessarily due to compromised oocyte quality after IVM, and that endometrial receptivity should also be considered, especially in IVM cycles where the follicular phase is dramatically shortened.
5. Clark DA
Should anti-TNF-alpha therapy be offered to patients with infertility and recurrent spontaneous abortion?
Am J Reprod Immunol. 2009 Feb;61(2):107-12
McMaster University, 1200 Main St. West. Rm 3V39, Hamilton, ON, Canada L8N3Z5. clarkd@mcmaster.ca
6. Gerber-Epstein P, Leichtentritt RD, Benyamini Y
The experience of miscarriage in first pregnancy: the women's voices
Death Stud. 2009 Jan;33(1):1-29
Bob Shapell School of Social Work, Tel Aviv University, Tel Aviv, Israel.
The study is a qualitative analysis of 19 interviews with Israeli women who have lost a first pregnancy to miscarriage. Neither the public nor health care professionals are fully aware of the implications and significance of miscarriage to the woman who has lost the pregnancy. The goal of this study was to understand and give voice to the women's experience. Five themes were revealed--the greater the joy, the more painful the crash; the nature and intensity of the loss; sources of support; life after the miscarriage; and recommendations to professionals. The experience of miscarriage was found to be grounded in the meaning of being a woman, as the loss of the pregnancy undermines the women's basic belief in their fertility and as a result threatens their meaning and role as women.
Prepared by the
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Loss Resource Center
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