NSIDRC Journal Article Alert — January 8, 2010

Prepared by the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University.

These articles have been selected from PubMed, a service of the National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to 1948. PubMed includes links to full text articles and other related resources.

Availability of full-text journal articles is often limited to subscribers or through inter-library loan. Please see your local library for copies of these articles, or view PubMed's How to Get the Journal Article or Partners in Information Access for the Public Health Workforce's How to Access Journal Articles for more details.

Past issues of Resource Center Journal Alerts

Miscarriage/Stillbirth/Prenatal Issues

1. Kovac M, Mitic G, Mikovic Z, Djordjevic V, Savic O, Mandic V, Rakicevic LJ, Antonijevic N, Radojkovic D
Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism
Gynecol Obstet Invest. 2010 Jan 8;69(4):233-238. [Epub ahead of print]

Blood Transfusion Institute of Serbia, Haemostasis Department, Clinical Centre of Serbia, Belgrade, Serbia.

Backgound/Aims: Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. Methods: To investigate the relationship between pregnancy-associated complications and the presence of thrombophilia, we studied the records of 453 women with pregnancy-associated complications. In 55 women, intrauterine fetal death (fetus mortus in utero, FMU) after 20 weeks of gestation was recorded, in 231 two or more consecutive recurrent fetal losses (RFL) were recorded, while 167 had a venous thromboembolism (VTE) during one of their pregnancies. The control group consisted of 128 healthy women, with no previous history of thrombotic events or miscarriages. Results: In the FMU group we found 54.5% of women had thrombophilia, in the RFL group 38%, and in the VTE group 52.7%. The most frequent thrombophilia in the VTE group was the FV Leiden (OR 17.9, 95% CI 4.2-75.9). The most frequent thrombophilia in the FMU group was the FII G20210A (OR 7.09, 95% CI 1.8-27.9). Statistical difference between RFL and the control group was observed only for FV Leiden (OR 6.8, 95% CI 1.6-29.7). Conclusion: Thrombophilia was found to be considerably more common in women with pregnancy-associated complications in comparison with the women with normal pregnancies, most frequently in patients with VTE or FMU. Copyright © 2010 S. Karger AG, Basel.

2. Suzuki S, Hiraizumi Y, Satomi M
History of abortion and perinatal outcomes associated with preeclampsia in nulliparous Japanese women
J Matern Fetal Neonatal Med. 2010 Jan 11. [Epub ahead of print]

Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan.

The purpose of the present study was to examine the influence of history of abortion on the next pregnancy outcomes associated with preeclampsia. This investigation involved 5206 nulliparous Japanese women with singleton pregnancies who delivered after 22 weeks of gestation. The patients were divided into two groups: those with a history of spontaneous and/or artificial abortion during the previous pregnancies after the marriage with the same partner (n = 1029) and those without a history of abortion (n = 4173). There was no significant difference in the incidence of preeclampsia between the 2 groups with and without previous abortions (4.0% vs. 3.9%, p = 0.91). In addition, there were no significant differences in the incidence of perinatal complications associated with preeclampsia between the 2 groups. Although further studies may be needed, based on the current results history of abortion does not seem to affect perinatal outcomes associated with preeclampsia.

3. Salihu HM, Alio AP, Belogolovkin V, Aliyu MH, Wilson RE, Reddy UM, Bruder K, Whiteman VE
Prepregnancy Obesity and Risk of Stillbirth in Viable Twin Gestations
Obesity (Silver Spring). 2010 Jan 7. [Epub ahead of print]

[1] Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida, USA [2] Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida, USA [3] The Chiles Center for Healthy Mothers and Babies, University of South Florida, Tampa, Florida, USA.

We sought to estimate the impact of prepregnancy obesity on demise of one or both fetuses in twin gestations. We performed a retrospective cohort study using the Missouri maternally linked cohort files (years 1989-2005). Prepregnancy obesity was defined as a BMI >/=30. Outcomes of interest were stillbirth (intrauterine fetal death at >/=20 weeks' gestation) and demise of one (partial loss) or both (complete loss) fetuses, regardless of the cause. We used Cox Proportional Hazards with correction for intracluster correlation to obtain risk estimates. The overall stillbirth rate for twin gestations was 15.5/1,000 (18.4/1,000 vs. 14.5/1,000 in obese and normal weight mothers, respectively; P = 0.02). The rate for complete fetal loss was higher in obese mothers (8.3/1,000 vs. 5.6/1,000; P = 0.01) but was comparable for partial fetal loss (19.1/1,000 for obese vs. 16.3/1,000 for normal weight mothers; P = 0.1). Adjusted estimates confirmed these findings (adjusted hazards ratio (AHR) and 95% confidence interval (CI) = 1.31 (1.02-1.68) for stillbirth; AHR = 1.59; CI = 1.01-2.51) for complete loss; and AHR = 1.21; CI = 0.91-1.62) for partial loss. Subanalysis conducted on stillbirth showed that the risk associated with obesity was only elevated for same-sex (AHR = 1.54; CI = 1.15-2.04) but not opposite-sex twins (0.99; CI = 0.56-1.75). Our findings may find utility in counseling of obese women with twin gestations.

Prepared by the
National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center
Georgetown University
2115 Wisconsin Avenue, N.W., Suite 601
Washington, DC 20007
(866) 866-7437 toll free
(202) 687-7466 local
(202) 784-9777 fax
info@sidscenter.org
http://www.sidscenter.org


	Home About A-Z Topics Contact FAQ's Links Publications Search Site Map
	Center Resources Bereavement Support Bibliographies Child Care and SIDS Definitions En Español First Responders For Families Infant Mortality Journal Alerts MCH Alert Multimedia Pregnancy Loss Professional Resources Safe Sleep Environment Statistics Training Toolkit Partner SIDS/ID Centers National SIDS & Infant Death Program Support Center / First Candle National SIDS & Infant Death Project IMPACT National Center for Cultural Competence SIDS/ID Project For more information on maternal and child health topics, visit the MCH Library	NSIDRC Journal Article Alert — January 8, 2010 Prepared by the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University. More about PubMed Copyright and Disclaimers These articles have been selected from PubMed, a service of the National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to 1948. PubMed includes links to full text articles and other related resources. Availability of full-text journal articles is often limited to subscribers or through inter-library loan. Please see your local library for copies of these articles, or view PubMed's How to Get the Journal Article or Partners in Information Access for the Public Health Workforce's How to Access Journal Articles for more details. Past issues of Resource Center Journal Alerts Miscarriage/Stillbirth/Prenatal Issues 1. Kovac M, Mitic G, Mikovic Z, Djordjevic V, Savic O, Mandic V, Rakicevic LJ, Antonijevic N, Radojkovic D Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism Gynecol Obstet Invest. 2010 Jan 8;69(4):233-238. [Epub ahead of print] Blood Transfusion Institute of Serbia, Haemostasis Department, Clinical Centre of Serbia, Belgrade, Serbia. Backgound/Aims: Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. Methods: To investigate the relationship between pregnancy-associated complications and the presence of thrombophilia, we studied the records of 453 women with pregnancy-associated complications. In 55 women, intrauterine fetal death (fetus mortus in utero, FMU) after 20 weeks of gestation was recorded, in 231 two or more consecutive recurrent fetal losses (RFL) were recorded, while 167 had a venous thromboembolism (VTE) during one of their pregnancies. The control group consisted of 128 healthy women, with no previous history of thrombotic events or miscarriages. Results: In the FMU group we found 54.5% of women had thrombophilia, in the RFL group 38%, and in the VTE group 52.7%. The most frequent thrombophilia in the VTE group was the FV Leiden (OR 17.9, 95% CI 4.2-75.9). The most frequent thrombophilia in the FMU group was the FII G20210A (OR 7.09, 95% CI 1.8-27.9). Statistical difference between RFL and the control group was observed only for FV Leiden (OR 6.8, 95% CI 1.6-29.7). Conclusion: Thrombophilia was found to be considerably more common in women with pregnancy-associated complications in comparison with the women with normal pregnancies, most frequently in patients with VTE or FMU. Copyright © 2010 S. Karger AG, Basel. 2. Suzuki S, Hiraizumi Y, Satomi M History of abortion and perinatal outcomes associated with preeclampsia in nulliparous Japanese women J Matern Fetal Neonatal Med. 2010 Jan 11. [Epub ahead of print] Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan. The purpose of the present study was to examine the influence of history of abortion on the next pregnancy outcomes associated with preeclampsia. This investigation involved 5206 nulliparous Japanese women with singleton pregnancies who delivered after 22 weeks of gestation. The patients were divided into two groups: those with a history of spontaneous and/or artificial abortion during the previous pregnancies after the marriage with the same partner (n = 1029) and those without a history of abortion (n = 4173). There was no significant difference in the incidence of preeclampsia between the 2 groups with and without previous abortions (4.0% vs. 3.9%, p = 0.91). In addition, there were no significant differences in the incidence of perinatal complications associated with preeclampsia between the 2 groups. Although further studies may be needed, based on the current results history of abortion does not seem to affect perinatal outcomes associated with preeclampsia. 3. Salihu HM, Alio AP, Belogolovkin V, Aliyu MH, Wilson RE, Reddy UM, Bruder K, Whiteman VE Prepregnancy Obesity and Risk of Stillbirth in Viable Twin Gestations Obesity (Silver Spring). 2010 Jan 7. [Epub ahead of print] [1] Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida, USA [2] Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida, USA [3] The Chiles Center for Healthy Mothers and Babies, University of South Florida, Tampa, Florida, USA. We sought to estimate the impact of prepregnancy obesity on demise of one or both fetuses in twin gestations. We performed a retrospective cohort study using the Missouri maternally linked cohort files (years 1989-2005). Prepregnancy obesity was defined as a BMI >/=30. Outcomes of interest were stillbirth (intrauterine fetal death at >/=20 weeks' gestation) and demise of one (partial loss) or both (complete loss) fetuses, regardless of the cause. We used Cox Proportional Hazards with correction for intracluster correlation to obtain risk estimates. The overall stillbirth rate for twin gestations was 15.5/1,000 (18.4/1,000 vs. 14.5/1,000 in obese and normal weight mothers, respectively; P = 0.02). The rate for complete fetal loss was higher in obese mothers (8.3/1,000 vs. 5.6/1,000; P = 0.01) but was comparable for partial fetal loss (19.1/1,000 for obese vs. 16.3/1,000 for normal weight mothers; P = 0.1). Adjusted estimates confirmed these findings (adjusted hazards ratio (AHR) and 95% confidence interval (CI) = 1.31 (1.02-1.68) for stillbirth; AHR = 1.59; CI = 1.01-2.51) for complete loss; and AHR = 1.21; CI = 0.91-1.62) for partial loss. Subanalysis conducted on stillbirth showed that the risk associated with obesity was only elevated for same-sex (AHR = 1.54; CI = 1.15-2.04) but not opposite-sex twins (0.99; CI = 0.56-1.75). Our findings may find utility in counseling of obese women with twin gestations. Prepared by the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center Georgetown University 2115 Wisconsin Avenue, N.W., Suite 601 Washington, DC 20007 (866) 866-7437 toll free (202) 687-7466 local (202) 784-9777 fax info@sidscenter.org http://www.sidscenter.org
	Accessibility • Copyright © Georgetown University • (866) 866-7437 (toll free) • (202) 687-7466 (local) 2115 Wisconsin Avenue, NW, Suite 601 • Washington, DC 20007 • info@sidscenter.org • (202) 784-9777 (fax)

Center Resources

Partner SIDS/ID Centers

For more information on maternal and child health topics, visit the MCH Library

NSIDRC Journal Article Alert — January 8, 2010

Partner SIDS/ID
Centers