NSIDRC Journal Article Alert — October 22, 2010
Prepared by the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University.
These articles have been selected from PubMed, a service of the National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to 1948. PubMed includes links to full text articles and other related resources.
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Bereavement
1. Aho AL, Astedt-Kurki P, Tarkka MT, Kaunonen M
Development and implementation of a bereavement follow-up intervention
for grieving fathers: an action research
J Clin Nurs. 2010 Oct 14. doi: 10.1111/j.1365-2702.2010.03523.x. [Epub
ahead of print]
Authors: Anna L Aho, MNSc, Doctoral Student and Senior Assistant Professor, Department of Nursing Science, University of Tampere; Päivi Åstedt-Kurki, PhD, Professor and Head of Department, University of Tampere, Department of Nursing Science, University of Tampere; Marja-Terttu Tarkka, PhD, Senior Assistant Professor, Department of Nursing Science, University of Tampere; Marja Kaunonen, PhD, Adjunct Professor and Senior Assistant Professor, Department of Nursing Science, University of Tampere, Tampere, Finland.
Aims and objectives. The aim is to present the development and implementation
of a bereavement follow-up intervention for grieving fathers. The development
and implementation process and components of the intervention are presented.
Background. There is a lack of research into fathers' grief and bereavement
support for them after the death of a child. Promotion of evidence-based
nursing requires transparent development and implementation of nursing
interventions and models to be able to repeat, evaluate their effectiveness
and redevelop them. Design. Phases of action research were used when
developing and implementing the intervention. Methods. Results of
the baseline study of father's grief and social support, the study
of current bereavement support and the literature review were combined
using triangulation. Results. In this action research, the development
of a bereavement follow-up intervention for grieving fathers began
with the planning phase that included a baseline study about fathers'
grief and social support, a study of current bereavement support systems
in Finnish university hospitals and a systematic review of literature
on the topic area and collaboration with a panel of experts. The developed
bereavement follow-up intervention included three complementary components:
support package, peer supporters' contact and health care personnel's
contact. Implementation of the intervention included the development
of a programme to be used in nursing practice, intervention training
for programme implementers and intervention implementation. Conclusions.
Developing and implementing an intervention is a complex, demanding
and long-term process. The planning required theoretical knowledge
as well as understanding the experiences of fathers, nursing practice
and collaboration with those who implemented the intervention. Relevance
to clinical practice. New information about the fathers' grief and
bereavement follow-up support is described. The model developed is
evidence-based and can be applied in nursing care where grieving fathers
and families are met.
© 2010 Blackwell Publishing Ltd.
Miscarriage/Stillbirth/Prenatal Issues
1. [No authors listed]
Aspirin alone or combined with nadroparin did not increase live birth
rates in women with unexplained recurrent miscarriage
Ann Intern Med. 2010 Oct 19;153(8):JC47
2. Traina E, Daher S, Moron AF, Sun SY, Franchim CS, Mattar R
Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes
in women with recurrent spontaneous abortion
J Reprod Immunol. 2010 Oct 16. [Epub ahead of print]
Obstetrics Departament, Universidade Federal de São Paulo, São Paulo, Brazil.
Hormonal, inflammatory and vascular alterations during pregnancy are
thought to be involved in pregnancy loss. The role of progesterone,
the actions of which involve cytokines and vascular endothelial growth
factor (VEGF), has been thoroughly studied. Genetic factors are involved
in modulation of these molecules, and several genes have been associated
with recurrent spontaneous abortion (RSA), as well other obstetric
conditions. Here we investigate the relationship between RSA and gene
polymorphisms of the progesterone receptor (PROGINS), interleukin-1
receptor 1 (PstI) and vascular endothelial growth factor (VEGF) (-634,
936). This case-controlled study comprised a total of 89 women with
idiopathic RSA and a control group of 191 women with at least two successful
pregnancies and no miscarriages. Genomic DNA was extracted from whole
blood, and polymorphism genotyping was conducted by digesting PCR products
with specific restriction endonucleases. No correlations were found
in any of the investigated polymorphisms, even among dominant, co-dominant
and additive inheritance models and alleles. Our results support the
hypothesis that these specific gene polymorphisms are not the major
determinant of pregnancy success. Although we did not find any correlations,
the investigation of these and other polymorphisms remains a challenge
in the evaluation of RSA.
Copyright © 2010. Published by Elsevier Ireland Ltd.
3. Xing X, Yan J, Zhao Y, You L, Bian Y, Chen ZJ
Association of Vascular Endothelial Growth Factor Gene Polymorphisms
with Recurrent Spontaneous Abortion in Chinese Han Women
Am J Reprod Immunol. 2010 Oct 18. doi: 10.1111/j.1600-0897.2010.00924.x.
[Epub ahead of print]
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China Shandong University School of Medicine, Jinan, Shandong, China.
Citation Xing X, Yan J, Zhao Y, You L, Bian Y, Chen Z-J. Association
of vascular endothelial growth factor gene polymorphisms with recurrent
spontaneous abortion in Chinese Han women. Am J Reprod Immunol 2010
Problem An association of polymorphism -1154G/A (rs1570360) in vascular
endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous
abortion (RSA) has been found in Caucasians. The aim of this study
was to examine the association of VEGF -1154 with RSA in a well-defined
group of Chinese Han patients. Method of study The VEGF -1154G/A genotype
was detected by real-time PCR with TaqMan probes. The products were
also subjected to gene sequence analysis to validate the PCR results.
Results The allele frequencies of VEGF -1154G/A showed no significant
difference between RSA patients and the normal controls (P = 0.183).
The frequencies of VEGF -1154G/A genotypes were not significantly different
between RSA patients and the normal controls (P = 0.228). Conclusion
Our study revealed that VEGF -1154G/A polymorphism was not associated
with the susceptibility to RSA in Chinese Han women.
© 2010 John Wiley & Sons A/S.
4.Tul NX, Verdenik I, Novak XD, Sr X0161 En TP, Blickstein I
Prospective risk of stillbirth in monochorionic-diamniotic twin gestations:
a population based study
J Perinat Med. 2010 Oct 14. [Epub ahead of print]
Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Centre Ljubljana, Slovenia.
Abstract Objective: To calculate a population-based prospective risk of fetal death in monochorionic-diamniotic twins. Study design: We evaluated 387 monochorionic-diamniotic twin pregnancies that were followed and delivered after 24 weeks in Slovenia during the period 1997–2007. Surveillance was not standardized. The prospective risk of fetal death was calculated as the total number of deaths after the beginning of the gestational period divided by the number of continuing pregnancies at or beyond that period. Results: Fetal death rate was 32 of 774 fetuses (4.1%; 95% confidence interval (CI), 3.0%–5.9%); the prospective risk of stillbirth per pregnancy after 33 weeks of gestation was 6.2% (95% CI, 4.2%–9.1%). Conclusion: The Slovenian population-based prospective risk of fetal death in monochorionic-diamniotic pregnancies that remained undelivered after 33 weeks' gestation is higher than previously reported from hospital-based studies.
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