Fetal Movement Monitoring:
A Selected Annotated Bibliography

These articles have been selected by Resource Center staff from PubMed, a service of the National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to 1948. PubMed includes links to full text articles and other related resources.

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Honest H, Forbes C, Durée Kh, Norman G, Duffy S, Tsourapas A, Roberts T, Barton P, Jowett S, Hyde C, Khan K.
Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling.
Health Technol Assess. 2009 Sep;13(43):1-627.

OBJECTIVES: To identify combinations of tests and treatments to predict and prevent spontaneous preterm birth. DATA SOURCES: Searches were run on the following databases up to September 2005 inclusive: MEDLINE, EMBASE, DARE, the Cochrane Library (CENTRAL and Cochrane Pregnancy and Childbirth Group trials register) and MEDION. We also contacted experts including the Cochrane Pregnancy and Childbirth Group and checked reference lists of review articles and papers that were eligible for inclusion. REVIEW METHODS: Two series of systematic reviews were performed: (1) accuracy of tests for the prediction of spontaneous preterm birth in asymptomatic women in early pregnancy and in women symptomatic with threatened preterm labour in later pregnancy; (2) effectiveness of interventions with potential to reduce cases of spontaneous preterm birth in asymptomatic women in early pregnancy and to reduce spontaneous preterm birth or improve neonatal outcome in women with a viable pregnancy symptomatic of threatened preterm labour. For the health economic evaluation, a model-based analysis incorporated the combined effect of tests and treatments and their cost-effectiveness. RESULTS: Of the 22 tests reviewed for accuracy, the quality of studies and accuracy of tests was generally poor. Only a few tests had LR+ > 5. In asymptomatic women these were ultrasonographic cervical length measurement and cervicovaginal prolactin and fetal fibronectin screening for predicting spontaneous preterm birth before 34 weeks. In this group, tests with LR- < 0.2 were detection of uterine contraction by home uterine monitoring and amniotic fluid C-reactive protein (CRP) measurement. In symptomatic women with threatened preterm labour, tests with LR+ > 5 were absence of fetal breathing movements, cervical length and funnelling, amniotic fluid interleukin-6 (IL-6), serum CRP for predicting birth within 2-7 days of testing, and matrix metalloprotease-9, amniotic fluid IL-6, cervicovaginal fetal fibronectin and cervicovaginal human chorionic gonadotrophin (hCG) for predicting birth before 34 or 37 weeks. In this group, tests with LR- < 0.2 included measurement of cervicovaginal IL-8, cervicovaginal hCG, cervical length measurement, absence of fetal breathing movement, amniotic fluid IL-6 and serum CRP, for predicting birth within 2-7 days of testing, and cervicovaginal fetal fibronectin and amniotic fluid IL-6 for predicting birth before 34 or 37 weeks. The overall quality of the trials included in the 40 interventional topics reviewed for effectiveness was also poor. Antibiotic treatment was generally not beneficial but when used to treat bacterial vaginosis in women with intermediate flora it significantly reduced the incidence of spontaneous preterm birth. Smoking cessation programmes, progesterone, periodontal therapy and fish oil appeared promising as preventative interventions in asymptomatic women. Non-steroidal anti-inflammatory agents were the most effective tocolytic agent for reducing spontaneous preterm birth and prolonging pregnancy in symptomatic women. Antenatal corticosteroids had a beneficial effect on the incidence of respiratory distress syndrome and the risk of intraventricular haemorrhage (28-34 weeks), but the effects of repeat courses were unclear. For asymptomatic women, costs ranged from 1.08 pounds for vitamin C to 1219 pounds for cervical cerclage, whereas costs for symptomatic women were more significant and varied little, ranging from 1645 pounds for nitric oxide donors to 2555 pounds for terbutaline; this was because the cost of hospitalisation was included. The best estimate of additional average cost associated with a case of spontaneous preterm birth was approximately 15,688 pounds for up to 34 weeks and 12,104 pounds for up to 37 weeks. Among symptomatic women there was insufficient evidence to draw firm conclusions for preventing birth at 34 weeks. Hydration given to women testing positive for amniotic fluid IL-6 was the most cost-effective test-treatment combination. Indomethacin given to all women without any initial testing was the most cost-effective option for preventing birth before 37 weeks among symptomatic women. For a symptomatic woman, the most cost-effective test-treatment combination for postponing delivery by at least 48 h was the cervical length (15 mm) measurement test with treatment with indomethacin for all those testing positive. This combination was also the most cost-effective option for postponing delivery by at least 7 days. Antibiotic treatment for asymptomatic bacteriuria of all women without any initial testing was the most cost-effective option for preventing birth before 37 weeks among asymptomatic women but this does not take into account the potential side effects of antibiotics or issues such as increased resistance. CONCLUSIONS: For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

Flenady V, MacPhail J, Gardener G, Chadha Y, Mahomed K, Heazell A, Fretts R, Frøen F.
Detection and management of decreased fetal movements in Australia and New Zealand: a survey of obstetric practice.
Aust N Z J Obstet Gynaecol. 2009 Aug;49(4):358-63.

BACKGROUND: Decreased fetal movement (DFM) is associated with increased risk of adverse pregnancy outcome. However, there is limited research to inform practice in the detection and management of DFM. AIMS: To identify current practices and views of obstetricians in Australia and New Zealand regarding DFM. METHODS: A postal survey of Fellows and Members, and obstetric trainees of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. RESULTS: Of the 1700 surveys distributed, 1066 (63%) were returned, of these, 805 (76% of responders) were currently practising and included in the analysis. The majority considered that asking women about fetal movement should be a part of routine care. Sixty per cent reported maternal perception of DFM for 12 h was sufficient evidence of DFM and 77% DFM for 24 h. KICK charts were used routinely by 39%, increasing to 66% following an episode of DFM. Alarm limits varied, the most commonly reported was < 10 movements in 12 h (74%). Only 6% agreed with the internationally recommended definition of < 10 movements in two hours. Interventions for DFM varied, while 81% would routinely undertake a cardiotocograph, 20% would routinely perform ultrasound and 20% more frequent antenatal visits. CONCLUSIONS: While monitoring fetal movement is an important part of antenatal care in Australia and New Zealand, variation in obstetric practice for DFM is evident. Large-scale randomised controlled trials are required to identify optimal screening and management options. In the interim, high quality clinical practice guidelines using the best available advice are needed to enhance consistency in practice including advice provided to women.

Verbeek RJ, van der Hoeven JH, Sollie KM, Maurits NM, Bos AF, den Dunnen WF, Brouwer OF, Sival DA.
Muscle ultrasound density in human fetuses with spina bifida aperta.
Early Hum Dev. 2009 Aug;85(8):519-23. Epub 2009 May 17.

BACKGROUND: In fetal spina bifida aperta (SBA), leg movements caudal to the meningomyelocele (MMC) are transiently present, but they disappear shortly after birth. Insight in the underlying mechanism could help to improve treatment strategies. In fetal SBA, the pathogenesis of neuromuscular damage prior to movement loss is still unknown. We reasoned that prenatal assessment of muscle ultrasound density (fetal-MUD) could help to reveal whether progressive neuromuscular damage is present in fetal SBA, or not. AIM: To reveal whether prenatal neuromuscular damage is progressively present in SBA. PATIENTS/METHODS: In SBA fetuses (n=6; 22-37 weeks gestational age), we assessed fetal-MUD in myotomes caudal to the MMC and compared measurements between myotomes cranial to the MMC and controls (n=11; 17-36 weeks gestational age). Furthermore, we intra-individually compared MUD and muscle histology between the pre- and postnatal period. RESULTS: Despite persistently present fetal leg movements caudal to the MMC, fetal-MUD was higher caudal to the MMC than in controls (p<0.05). Fetal-MUD caudal to the MMC did not increase with gestational age, whereas fetal-MUD in controls and cranial to the MMC increased with gestational age (p<0.05). In 5 of 6 patients assessed, comparison between pre- and postnatal MUD and/or muscle histology indicated consistent findings. CONCLUSIONS: In fetal SBA, persistent leg movements concur with stable, non-progressively increased fetal-MUD. These data may implicate that early postnatal loss of leg movements is associated with the impact of additional neuromuscular damage after the prenatal period.

Tveit JV, Saastad E, Stray-Pedersen B, Børdahl PE, Flenady V, Fretts R, Frøen JF.
Reduction of late stillbirth with the introduction of fetal movement information and guidelines - a clinical quality improvement.
BMC Pregnancy Childbirth. 2009 Jul 22;9:32.

BACKGROUND: Women experiencing decreased fetal movements (DFM) are at increased risk of adverse outcomes, including stillbirth. Fourteen delivery units in Norway registered all cases of DFM in a population-based quality assessment. We found that information to women and management of DFM varied significantly between hospitals. We intended to examine two cohorts of women with DFM before and during two consensus-based interventions aiming to improve care through: 1) written information to women about fetal activity and DFM, including an invitation to monitor fetal movements, 2) guidelines for management of DFM for health-care professionals. METHODS: All singleton third trimester pregnancies presenting with a perception of DFM were registered, and outcomes collected independently at all 14 hospitals. The quality assessment period included April 2005 through October 2005, and the two interventions were implemented from November 2005 through March 2007. The baseline versus intervention cohorts included: 19,407 versus 46,143 births and 1215 versus 3038 women with DFM, respectively. RESULTS: Reports of DFM did not increase during the intervention. The stillbirth rate among women with DFM fell during the intervention: 4.2% vs. 2.4%, (OR 0.51 95% CI 0.32-0.81), and 3.0/1000 versus 2.0/1000 in the overall study population (OR 0.67 95% CI 0.48-0.93). There was no increase in the rates of preterm births, fetal growth restriction, transfers to neonatal care or severe neonatal depression among women with DFM during the intervention. The use of ultrasound in management increased, while additional follow up visits and admissions for induction were reduced. CONCLUSION: Improved management of DFM and uniform information to women is associated with fewer stillbirths.

Khooshideh M, Izadi S, Shahriari A, Mirteymouri M.
The predictive value of ultrasound assessment of amniotic fluid index, biophysical profile score, nonstress test and foetal movement chart for meconium-stained amniotic fluid in prolonged pregnancies.
J Pak Med Assoc. 2009 Jul;59(7):471-4.

OBJECTIVE: To evaluate the value of non-stress test (NST), biophysical profile score (BPS), amniotic fluid index (AFI) and foetal movement charted (FMC) by mother in the prediction of meconium passage in post-date pregnancies. METHODS: In a cross-sectional study performed from 2003 to 2005, in the Ali-Ebne-Abitaleb Hospital, all post-date singleton pregnant women were included and evaluated a few hours before delivery for AFI, NST, BPS and FMC. Based on the results of the mentioned tests the occurrence of foetal distress was foreseen and the judgments were compared with the results of evaluation of the amniotic fluid after amniotomy during labour. Our judgment of occurrence of foetal distress was based on meconium staining of amniotic fluid (MSAF) as the gold standard. RESULTS: In this study 250 women were included. The sensitivity and specificity of these tests respectively were: 62% and 42% for NST, 66% and 56% for BPS, 38% and 83% for AFI and 44% and 64% for FMC. The highest positive predictive value was recorded respectively for AFI (52%) and negative predictive value was recorded for NST (94%). There was a significant association between MSAF and BPS. In univariate analyses, there was a significant association between MSAF and BPS (P = 0.010 for linear by linear association, exact method). Also there was a significant association between MSAF and AFI < 5 cm. (OR = 2.99, 95% CI, 1.57-5.74). CONCLUSION: Although BPS and AFI had the highest level of prediction, they are of limited usefulness in prediction of foetal distress. The reactive NST is more conclusive.

Haws RA, Yakoob MY, Soomro T, Menezes EV, Darmstadt GL, Bhutta ZA.
Reducing stillbirths: screening and monitoring during pregnancy and labour.
BMC Pregnancy Childbirth. 2009 May 7;9 Suppl 1:S5.

BACKGROUND: Screening and monitoring in pregnancy are strategies used by healthcare providers to identify high-risk pregnancies so that they can provide more targeted and appropriate treatment and follow-up care, and to monitor fetal well-being in both low- and high-risk pregnancies. The use of many of these techniques is controversial and their ability to detect fetal compromise often unknown. Theoretically, appropriate management of maternal and fetal risk factors and complications that are detected in pregnancy and labour could prevent a large proportion of the world's 3.2 million estimated annual stillbirths, as well as minimise maternal and neonatal morbidity and mortality. METHODS: The fourth in a series of papers assessing the evidence base for prevention of stillbirths, this paper reviews available published evidence for the impact of 14 screening and monitoring interventions in pregnancy on stillbirth, including identification and management of high-risk pregnancies, advanced monitoring techniques, and monitoring of labour. Using broad and specific strategies to search PubMed and the Cochrane Library, we identified 221 relevant reviews and studies testing screening and monitoring interventions during the antenatal and intrapartum periods and reporting stillbirth or perinatal mortality as an outcome. RESULTS: We found a dearth of rigorous evidence of direct impact of any of these screening procedures and interventions on stillbirth incidence. Observational studies testing some interventions, including fetal movement monitoring and Doppler monitoring, showed some evidence of impact on stillbirths in selected high-risk populations, but require larger rigourous trials to confirm impact. Other interventions, such as amniotic fluid assessment for oligohydramnios, appear predictive of stillbirth risk, but studies are lacking which assess the impact on perinatal mortality of subsequent intervention based on test findings. Few rigorous studies of cardiotocography have reported stillbirth outcomes, but steep declines in stillbirth rates have been observed in high-income settings such as the U.S., where cardiotocography is used in conjunction with Caesarean section for fetal distress. CONCLUSION: There are numerous research gaps and large, adequately controlled trials are still needed for most of the interventions we considered. The impact of monitoring interventions on stillbirth relies on use of effective and timely intervention should problems be detected. Numerous studies indicated that positive tests were associated with increased perinatal mortality, but while some tests had good sensitivity in detecting distress, false-positive rates were high for most tests, and questions remain about optimal timing, frequency, and implications of testing. Few studies included assessments of impact of subsequent intervention needed before recommending particular monitoring strategies as a means to decrease stillbirth incidence. In high-income countries such as the US, observational evidence suggests that widespread use of cardiotocography with Caesarean section for fetal distress has led to significant declines in stillbirth rates. Efforts to increase availability of Caesarean section in low-/middle-income countries should be coupled with intrapartum monitoring technologies where resources and provider skills permit.

Degani S, Leibovitz Z, Shapiro I, Ohel G.
Twins' temperament: early prenatal sonographic assessment and postnatal correlation.
J Perinatol. 2009 May;29(5):337-42. Epub 2009 Jan 22.

OBJECTIVE: To study inter-twin differences in activity during early pregnancy and to examine their relationship to subsequent infant twins' temperament. STUDY DESIGN: Measures of fetal motor activity (frequency, duration and number of movements) were collected from 26 twin pairs during ultrasound nuchal translucency scan at late first trimester and early second trimester (11 to 14 weeks gestation). In twenty-two patients, the twins were dizygotic (dichorionic); of them, 13 twin pairs were of different sexes, five were both females and four were both males. Of the four monozygotic twin pregnancies, two were dichorionic and two were monochorionic, three were both females.The more active fetus in each pair was noted according to the position and/or sex without reporting to parents. Reported maternal perception of the more active twin was documented at the mid-trimester anatomical scan. Maternally reported postnatal temperament data of the infants were collected at 3 and 6 months, using Rothbarts' Infant Behavior Questionnaire (IBQ). RESULTS: After birth, maternal reports on infants' temperament and the more active twin in each pair were in good correlation with prenatal inter-twin differences in activity. The receiver operating characteristic (ROC) curves shows a better performance of ultrasound compared with maternal perception in prediction of the more active twin. CONCLUSIONS: The features of fetal neurobehavioral activity provide the basis for individual differences in twins' activity in infancy. Differences in activity in early pregnancy even before the emergence of fetal behavioral patterns were followed by temperamental differences postnatally.

Jansson LM, Dipietro JA, Velez M, Elko A, Knauer H, Kivlighan KT.
Maternal methadone dosing schedule and fetal neurobehaviour.
J Matern Fetal Neonatal Med. 2009 Jan;22(1):29-35.

OBJECTIVE: Daily methadone maintenance is the standard of care for opiate dependency during pregnancy. Previous research has indicated that single-dose maternal methadone administration significantly suppresses fetal neurobehaviours. The purpose of this study was to determine if split-dosing would have less impact on fetal neurobehaviour than single-dose administration. METHODS: Forty methadone-maintained women were evaluated at peak and trough maternal methadone levels on single- and split-dosing schedules. Monitoring sessions occurred at 36- and 37-weeks gestation in a counterbalanced study design. Fetal measures included heart rate, variability, accelerations, motor activity and fetal movement-heart rate coupling (FM-FHR). Maternal measures included heart period, variability, skin conductance, respiration and vagal tone. Repeated measure analysis of variance was used to evaluate within-subject changes between split- and single-dosing regimens. RESULTS: All fetal neurobehavioural parameters were suppressed by maternal methadone administration, regardless of dosing regimen. Fetal parameters at peak were significantly lower during single versus split methadone administration. FM-FHR coupling was less suppressed from trough to peak during split-dosing versus single-dosing. Maternal physiologic parameters were generally unaffected by dosing condition. CONCLUSION: Split-dosed fetuses displayed less neurobehavioural suppression from trough to peak maternal methadone levels as compared with single-dosed fetuses. Split-dosing may be beneficial for methadone-maintained pregnant women.

Vullings R, Peters CH, Mischi M, Oei SG, Bergmans JW.
Fetal movement quantification by fetal vectorcardiography: a preliminary study.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1056-9.

Fetal movement is a valuable source of information to monitor the neurological development of the fetus and assess fetal health. Currently, fetal movement can be assessed by the mother or detected by analysis of ultrasound images. Long-term monitoring of movement is complicated with both these methods as maternal self-assessment has a relatively poor sensitivity and specificity and automatic analysis of ultrasound images is not available. Moreover, ultrasound transducers transmit energy into the body, potentially endangering fetal health. In this paper, an alternative method for fetal movement monitoring is presented. This method operates by estimating and analyzing the fetal vectorcardiogram (VCG) from non-invasive recordings on the maternal abdomen. The determined fetal movement is compared with that assessed from a simultaneously performed ultrasound recording; the results of the presented method are consistent with the ultrasound images. In addition, the presented method enables quantification of the rotation angles by means of analysis of the rotation matrix between consecutive fetal VCGs, providing a tool for long-term monitoring of fetal movement with increased specificity.

Heazell AE, Green M, Wright C, Flenady V, Frøen JF.
Midwives' and obstetricians' knowledge and management of women presenting with decreased fetal movements.
Acta Obstet Gynecol Scand. 2008;87(3):331-9.

BACKGROUND: Maternal perception of decreased fetal movements (DFM) affects 5-15% of pregnancies. DFM is associated with intra-uterine fetal death (IUFD) and intra-uterine growth restriction (IUGR). It has been proposed that maternal perception of DFM may be used as a screening tool for IUFD or IUGR. However, this proposal is complicated by variations in definitions and management of DFM. HYPOTHESIS: We hypothesised that uncertainties in the definition and management of women presenting with DFM leads to variation in clinical practice. METHODS: A postal questionnaire was sent to midwives and consultant obstetricians in the UK. RESULTS: The majority of respondents enquired about the presence of fetal movements after 28 weeks gestation. There was little agreement on a definition of DFM, with a maternal perception of decreased movements for 24 h gaining the greatest acceptance. Few practitioners used formal fetal movement counting, with the majority of respondents stating they were ineffective in the prevention of IUGR or IUFD and led to increased intervention. There was large variation in the knowledge of associations with DFM and management of women presenting with DFM. CONCLUSIONS: There were wide variations in the practice of obstetricians and midwives with regard to women presenting with DFM; many aspects of practice were not based on the available evidence. The variation in practice may result from a lack of robust evidence on which to base the provision of care. Further research is needed to provide and disseminate evidence to direct the management of women presenting with DFM.

Troyano Luque JM, Maeda K, Kurjak A, Merce L, Bajo-Arenas J, Pérez-Medina T.
Fetal extremity kinetics quantified with Doppler ultrasonography.
J Perinat Med. 2008;36(1):82-6.

AIMS: To assess the responsive fetal extremity movement to vibro-acoustic stimulation test (VAST). METHODS: The moving velocity of fetal femur was assessed after VAST by pulsed Doppler device. The ultrasonic beam was insonated at a right angle to the fetal femur. The following parameters were determined: limb retreat velocity in accelerative slope (Pk1); limb replenishment velocity in decelerative slope (Pk2); mean flexion to extension velocity; and the response time to VAST. Among 80 normal singleton pregnancies in 33-41 weeks, 68 were weekly evaluated and the others were assessed for two or more times during the study period, for a total of 680 studies of fetal kinetics. RESULTS: The Pk1 declined from 9.6 to 6.26 cm/s; Pk2 decreased from 2.6 to 1.3 cm/s; mean velocity was reduced from 6.0 to 4.25 cm/s; whereas the response time increased from 0.1 to 0.3 s throughout the study period, i.e., fetal response reduces and the response time increases as maturation progresses. CONCLUSION: The pulsed Doppler may assess fetal activity in any body structure. Reflex responses become slow and complex on both the velocity and response time as maturation increases with gestational age. Our observations have resulted in a novel and easy method for the quantitative assessment of fetal reflex reactivity to external stimuli.

Kurjak A, Tikvica A, Stanojevic M, Miskovic B, Ahmed B, Azumendi G, Di Renzo GC.
The assessment of fetal neurobehavior by three-dimensional and four-dimensional ultrasound.
J Matern Fetal Neonatal Med. 2008 Oct;21(10):675-84.

The development of three-dimensional (3D) and four-dimensional ultrasound (4D) has provided new opportunities to study fetal and even embryonic behavior. These techniques enable simultaneous spatial imaging of the entire fetus and its movements. Recently, multicenter studies of fetal brain function have been carried out, the aim of which is to establish the standards of embryonic and fetal peripheral and body movements and facial expression as additional diagnostic criteria for prenatal brain development. Additional studies have been conducted in order to provide more information on specific movement patterns and quality of movement in the high-risk fetus. The purpose of this paper is to review and analyze the published literature on the use of 3D and 4D ultrasound in the assessment of fetal behavior.

Nishihara K, Horiuchi S, Eto H, Honda M.
A long-term monitoring of fetal movement at home using a newly developed sensor: an introduction of maternal micro-arousals evoked by fetal movement during maternal sleep.
Early Hum Dev. 2008 Sep;84(9):595-603. Epub 2008 May 2.

BACKGROUND: Pregnant women's sleep disturbance due to fetal movement is well known. Fetal movement is thought to be an index of fetal well-being. However, as there has never been a way to easily and reliably record fetal movement, psychophysiological studies of pregnant women's sleep disturbance and fetal well-being have not been done. AIMS: To solve these methodological issues, we developed a new sensor with electrostatic capacity that can pick up acceleration of fetal movement. METHODS AND RESULTS: Experiment I: We verified the reliability of our fetal movement recording system. Thirty-two pregnant women (from 19 to 39 weeks of gestation) were asked to lie down on a bed for about 1 h and to press a button as a subjective marker when they felt fetal movement. We simultaneously recorded maternal polysonograms and fetal movement from the mothers' abdomens using a Medilog recorder. The mean of prevalence-adjusted bias-adjusted kappa for agreements, based on time between fetal movement signals recorded and subjective maternal markers, was substantial at 0.75. Experiment II: We recorded seven pregnant women's polysonograms and fetal movement simultaneously during all-night sleep at home using our sensor during weeks 33 and 36 of gestation. We succeeded in recording maternal micro-arousals evoked by fetal movement. The mean value of the number of micro-arousals at 33 weeks was slightly larger than that at 36 weeks. CONCLUSIONS: There was a high agreement between subjective maternal markers and fetal movement. Our recording system using the new sensor can be used for home monitoring of fetal movement.

Frøen JF, Heazell AE, Tveit JV, Saastad E, Fretts RC, Flenady V.
Fetal movement assessment.
Semin Perinatol. 2008 Aug;32(4):243-6.

Maternal perception of fetal movements is the oldest and most commonly used method to assess fetal well-being. While almost all pregnant women adhere to it, organized screening by fetal movements has seen variable popularity among health professionals. Early results of screening were promising and fetal movement counting is the only antepartum testing method that has shown effect in reducing mortality in a randomized controlled trial comparing testing versus no testing. Although awareness of fetal movements is associated with improved perinatal outcomes, the quest to define a quantitative "alarm limit" to define decreased fetal movements has so far been unsuccessful, and the use of most such limits developed for fetal movement counting should be discouraged.

Kuwata T, Matsubara S, Ohkusa T, Ohkuchi A, Izumi A, Watanabe T, Suzuki M.
Establishing a reference value for the frequency of fetal movements using modified 'count to 10' method.
J Obstet Gynaecol Res. 2008 Jun;34(3):318-23.

AIMS: To establish a reference value for the frequency of fetal movements perceived by the mother during the second half of pregnancy. METHODS: The study subjects consisted of 705 low risk Japanese pregnant women who continuously received antenatal care. We asked women to record the time required to perceive 10 fetal movements ('count to 10' time) everyday. We asked women to record it, not at a fixed time (i.e. evening time), but whenever they felt the fetus move the most actively. The position during counting (i.e. sitting position) was also not specified, and thus we named this method as modified 'count to 10' method. Satisfactory recordings were obtained from 690 women, which we used for analysis. RESULTS: The 'count to 10' time was almost the same from 22 weeks (10.9; 7.3-18.0 (median; interquartile range)) until 32 weeks (10.0; 6.2-15.6), and it Thirty-two weeks showed the shortest time, which gradually increased toward 40 weeks (14.8; 9.5-24.0). Its 90th percentile was approximately 25 and 35 min at 22-36 weeks and at 37-40 weeks, respectively. CONCLUSIONS: For the first time we established a reference value for perceived fetal movements throughout the second half of pregnancy. The present modified 'count to 10' method requires less time than the previous method. Approximately 98% (690/705) of women gave us satisfactory recordings. This reference value may be of use in identifying mothers with decreased fetal movements.

Heazell AE, Frøen JF.
Methods of fetal movement counting and the detection of fetal compromise.
J Obstet Gynaecol. 2008 Feb;28(2):147-54.

Maternal perception of fetal movements is widely used as a marker of fetal viability and well-being. A reduction in fetal movements is associated with fetal hypoxia, increased incidence of stillbirth and fetal growth restriction (FGR). Therefore, a reduction in fetal movements has been proposed as a screening tool for FGR or fetal compromise. The problem of this approach is that there is no widely accepted definition of reduced fetal activity or 'alarm limits', and pregnant women are currently given a wide range of non-evidence-based advice. We have reviewed the background of published definitions and their potential usefulness in screening. A formal meta-analysis of these studies is not possible due to variation in methodology and definitions of reduced fetal movements. Assessment of fetal movements using formal fetal movement counting has shown equivocal results. Importantly, in all studies, there was a decrease in perinatal mortality suggesting a beneficial role for raising maternal awareness of fetal movements. Most studies implemented limits to define reduced fetal movements based on small groups of high risk pregnancies and obsolete counting methodology. A single case-control study developed 'normal limits' in a low risk population, and successfully implemented it prospectively for screening. At present, there is no evidence that any absolute definition of reduced fetal movements is of greater value than maternal subjective perception of reduced fetal movements in the detection of intrauterine fetal death or fetal compromise. Further investigation is required to determine an effective method of identifying patients with reduced fetal movements and to determine the best subsequent management.

Habek D.
Effects of smoking and fetal hypokinesia in early pregnancy.
Arch Med Res. 2007 Nov;38(8):864-7. Epub 2007 Aug 3.

BACKGROUND: The aim of this study was to perform qualitative and quantitative ultrasound (US) monitoring of fetal movement in early pregnancy (gestational weeks 10-20) as a component of fetal behavior in women smokers. METHODS: The study included three groups of 20 pregnant women each: non-smokers (group 1), smokers of an average of 10 cigarettes daily (group 2), and smokers of an average of >20 cigarettes daily (chronic smokers; group 3). Two-dimensional US study was performed once during gestational weeks 10-20 by the then standard method of fetal movement monitoring: 1) quantitative measurement of global fetal movements qualitatively verified as brisk or sluggish; 2) quantitative measurement of isolated spontaneous head movements; 3) quantitative measurement of isolated spontaneous arm movements; 4) quantitative measurement of isolated spontaneous leg movements; and 5) M-mode measurement of fetal heart rate. RESULTS: The ratio of brisk to sluggish fetal movements was 82.8% to 17.2%, 79.01% to 20.98%, and 44.25% to 55.75% in groups 1, 2, and 3, respectively (p <0.001). The rate of isolated spontaneous head and arm movements and of the upper cerebral pattern (head and arm movements) was statistically significantly lower in group 3 as compared with groups 1 and 2 (p <0.001), whereas no statistical significance was recorded in isolated spontaneous leg movements (p >0.01). The rate of fetal tachycardia was also significant in group 3, whereas tachyarrhythmia was recorded in seven children born to group 3 mothers (p <0.001). CONCLUSIONS: The present study of the effect of chronic tobacco hypoxia on the components of fetal behavior revealed a positive correlation between global and isolated fetal hypokinesia of the upper cerebral pattern (p <0.001), fetal tachycardia, and tachyarrhythmia in the group of mothers who were chronic smokers (p <0.001).

de Vries JI, Fong BF.
Changes in fetal motility as a result of congenital disorders: an overview.
Ultrasound Obstet Gynecol. 2007 May;29(5):590-9.

After 35 years of real-time two-dimensional sonography, can we now identify changes in fetal motility indicative of malfunction of the central nervous system in high-risk pregnancies? A literature search on motor assessment procedures (movements specified for body part (SMP), quantity, quality and behavioral state), and motor milestones obtained per fetus (with various congenital disorders) yielded 48 articles describing motility of 104 fetuses. In 67%, SMPs (especially isolated arm or leg movements, breathing and general movements) were assessed. Quantitative aspects were examined in 76%, qualitative aspects in 62% and behavioral states in two fetuses. Abnormal motility can be divided into two main subcategories: hypo- and hyperkinetic, demonstrating decreased variation in qualitative performance (reduced or increased, respectively, amplitude, speed and number of participating body parts, abnormal quantity (reduced or increased, respectively) and reduced differentiation into SMPs. Posture was affected in 40/60 hypokinetic and 4/44 hyperkinetic moving fetuses. The majority of the disorders resulted in an adverse outcome. Fourteen percent survived with a handicap, depending on the underlying disorder. The 16 disorders with hypokinetic motility had mainly an autosomal recessive etiology with no possibility of invasive prenatal diagnosis or conclusive sonographic structural anomalies, in contrast to the 17 disorders with hyperkinetic motility. Within the limitations of the studies, a deeper understanding of affected milestones in motor development can be obtained. Broadening motor assessment procedures from quantitative only to include qualitative aspects, differentiation of SMPs and behavioral states and emphasizing onset and continuity of motility before and after birth will enhance the reliability and predictive value of motility as a parameter in the assessment of fetal condition. Copyright (c) 2007 ISUOG.

Gómez LM, De la Vega G, Padilla L, Bautista F, Villar A.
Compliance with a fetal movement chart by high-risk obstetric patients in a Peruvian hospital.
Am J Perinatol. 2007 Feb;24(2):89-93. Epub 2007 Jan 31.

We sought to determine the degree of compliance with a novel fetal movement chart (FMC) by high-risk patients versus the standard so-called count-to-10 method. This prospective trial included 1400 high-risk patients. Women with singleton gestations were randomly assigned to use either the count-to-10 chart or a FMC proposed by the Latin American Center for Perinatology (CLAP). Advantages and disadvantages were identified by patients. Compliance with regimens was measured and compared between the two groups. Demographic characteristics were similar. Compliance in the CLAP group (448 of 700) was lower than in the count-to-10 group (638 of 700; 64 versus 91%; P < 0.0001). The main advantage of the count-to-10 chart was lack of interference with daily activities. No intrauterine demises occurred in either group. High-risk patients were more compliant with the standard count-to-10 charting method than with the novel FMC. The count-to-10 method is an easy and inexpensive tool for fetal monitoring and should continue to be used in obstetric practice.

Mangesi L, Hofmeyr GJ.
Fetal movement counting for assessment of fetal wellbeing.
Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004909.

BACKGROUND: Fetal movement counting is a method by which a woman quantifies the movements she feels to assess the condition of the baby. The purpose is to try to reduce perinatal mortality by alerting caregivers when the baby might have become compromised. This method may be used routinely, or only in women who are considered at increased risk of complications in the baby. Some clinicians believe that fetal movement counting is a good method as it allows the clinician to make appropriate interventions in good time. On the other hand, fetal movement counting may cause anxiety to women. OBJECTIVES: To assess outcomes of pregnancy where fetal movement counting was done routinely, selectively or was not done at all; and to compare different methods of fetal movement counting. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2006), the Cochrane Central Register of Controlled Trials (The Cochrane Library) and the reference lists of relevant papers. SELECTION CRITERIA: Randomised controlled trials. Trials were excluded where allocation concealment was inadequate and no measures were taken to prevent bias were excluded. The interventions included routine fetal movement counting, selective fetal movement counting, and studies comparing different fetal assessment methods. DATA COLLECTION AND ANALYSIS: We assessed the methodological quality of included studies and extracted data from studies. MAIN RESULTS: Four studies, involving 71,370 women, were included in this review; 68,654 in one cluster-randomised trial. All four trials compared formal fetal movement counting. Two trials compared different types of counting with each other; one with no formal instruction, and one with hormonal analysis. Women in the formal fetal movement counting group had significantly fewer visits to the hospital antenatally than those women randomised to hormone analysis (relative risk (RR) 0.26, 95% confidence interval (CI) 0.20 to 0.35), whereas there were fewer Apgar scores less than seven in five minutes for women randomised to hormone analysis (RR 1.72, 95% CI 1.01 to 2.93).There was a significantly higher compliance with the Cardiff 'count to ten' method than with the formal fetal movement counting method (RR 0.25, 95% CI 0.19 to 0.32).All other outcomes reported were non significant. AUTHORS' CONCLUSIONS: This review does not provide enough evidence to influence practice. In particular, no trials compared fetal movement counting with no fetal movement counting. Robust research is needed in this area.

Sinha D, Sharma A, Nallaswamy V, Jayagopal N, Bhatti N.
Obstetric outcome in women complaining of reduced fetal movements.
J Obstet Gynaecol. 2007 Jan;27(1):41-3.

Reduction of fetal movements causes concern and anxiety and is a common indication for the assessment of fetal well-being. The aim of this study was to review the outcome of women who presented primarily with reduced fetal movements and to compare with women of similar age and gestation who did not present with reduced fetal movements (controls). Some 19% of intrauterine growth restricted babies were found in the study group, compared with none in the control group. In the study group, 32% of women needed intervention solely due to fetal compromise compared with 21% in the control group. There was no perinatal or neonatal death in either group. We suggest that these women should be carefully investigated and monitored to improve the obstetric outcome.

Su LL, Chong YS.
Common modalities for routine antepartum foetal monitoring: are they evidence-based?
Singapore Med J. 2006 Oct;47(10)830-5; quiz 836.

Antepartum foetal monitoring is crucial for the detection of foetuses at risk so that timely intervention can improve the perinatal outcome. The evidence underlying the most common modalities of antepartum foetal monitoring used are appraised and presented in this article. Foetal movement chart should be used in high-risk pregnancies but not recommended routinely in low-risk pregnancies. Symphysis-fundal height measurement, being associated with low cost and ease of use, is a reasonable screening tool for foetal well-being. Third trimester ultrasonography is, thus far, the best modality available for the assessment of foetal growth, and can be used until a better modality for foetal growth assessment becomes available. Antepartum cardiotocography can be used to monitor foetal well-being in normal pregnancies beyond the estimated date of delivery but it probably serves little purpose prior to that. Well-designed controlled studies evaluating modalities for antepartum foetal monitoring are generally lacking. With the advance of medical science, more research should be focused on this aspect of obstetric care so that our practice can become more evidence-based.

Wyatt SN, Rhoads SJ.
A primer on antenatal testing for neonatal nurses: part 2: tests of fetal well-being.
Adv Neonatal Care. 2006 Oct;6(5):228-41.

A number of new antenatal testing tools are being used in obstetric practice to evaluate the clinical picture of the fetus in utero. Results of these tests may prompt transfer to a tertiary facility for delivery or further antenatal monitoring. Part 2 of this 2-part series will describe antenatal testing methods used to determine fetal well-being, as well as highlight the emerging developments in the field of fetal surveillance. The ability to interpret antenatal testing results may help the neonatal team triage to assure bed availability, and predict and provide appropriate staffing for new admissions, and is an important foundation for subsequent neonatal risks and clinical care.

Zisser H, Jovanovic L, Thorsell A, Kupperman A, Taylor LJ, Ospina P, Hod M.
The fidgety fetus hypothesis: fetal activity is an additional variable in determining birth weight of offspring of women with diabetes.
Diabetes Care. 2006 Jan;29(1):63-7.

OBJECTIVE: To determine whether some offspring of women with diabetes are intrinsically more active than others in utero and whether those who are active are able to normalize their birth weight despite maternal hyperglycemia. RESEARCH DESIGN AND METHODS: We conducted a three-phase study to view the relationship between fetal movements and subsequent birth weight in women with diabetes. Phase I was designed to assess maternal perception of fetal movements in a population of 10 women with diabetes. To improve our fetal monitoring techniques, in phase II we analyzed fetal movements using the Card Guard home fetal monitoring device (CG 900P) in a population of 13 women with gestational diabetes mellitus (GDM). To apply our observations of fetal movements to a larger population, during phase III we conducted a retrospective analysis of fetal monitoring strips (HP 8041A) from 46 women with GDM to examine the relationship between fetal heart rate (FHR) accelerations and percentile birth weight, corrected for gestational age. RESULTS: Phase I confirmed that there is little variability in fetal movements (i.e., fetal kicks did not significantly deviate from one another on a day-to-day basis). In phase II, the fetal monitoring strips illustrated that the active fetuses (defined as > or = 4 FHR accelerations in a 20-min period) were always active, and the inactive fetuses were always inactive. The mean birth weight percentile, corrected for gestational age, in the active group was 37 vs. 63% in the inactive group (P = 0.05). In phase III, the fetal monitoring strips showed an inverse correlation between the mean number of FHR accelerations and the birth weight of the fetus, corrected for gestational age. The mean birth weight percentile in the active group was 37 vs. 62% in the inactive group (P = 0.0017). CONCLUSIONS: The fetus appears to play a role in determining its own destiny. Increased fetal activity may minimize the impact of hyperglycemia on subsequent birth weight. The inactive fetus appears to be at a higher risk for glucose-mediated macrosomia.

[No authors listed]
Management of pregnancy beyond 40 weeks' gestation.
Am Fam Physician. 2005 May 15;71(10):1935-41.

A post-term or prolonged pregnancy is one that reaches 42 weeks' gestation; approximately 5 to 10 percent of pregnancies are post-term. Studies have shown a reduction in the number of pregnancies considered post-term when early ultrasound dating is performed. Maternal and fetal risks increase with gestational age, but the management of otherwise low-risk prolonged pregnancies is controversial. Antenatal surveillance with fetal kick counts, nonstress testing, amniotic fluid index measurement, and biophysical profiles is used, although no data show that monitoring improves outcomes. Studies show a reduction in the rate of cesarean deliveries and possibly in neonatal mortality with a policy of routine labor induction at 41 weeks' gestation.

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October 2009

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